Do not use -s flag. clang says it ignores it, yet with some versions of clang the build then fails. --- setup.py.orig 2009-03-14 12:32:21.000000000 -0500 +++ setup.py 2020-01-12 12:06:26.000000000 -0600 @@ -16,8 +16,6 @@ ext_modules=[ Extension('clnum.clnum', ['clnum/src/clnum.cpp', ], libraries=['cln', 'gmp'], - # Remove symbols. - extra_link_args=['-s'], ), ], )